In 1973, the Penn sophomore recorded a 9-2 mark from the mound for the Quakers and was named the Walter O'Malley Most Valuable Player. Muhlstock finished his first season as the Ivy League/Eastern Intercollegiate Baseball League (EIBL) pitching leader, recording a 6-1 mark in league play for second place. He was named second-team All-Ivy League and All-EIBL and was honored with All-District 2 All-Star accolades. Muhlstock was instrumental in Penn's best season (19-12-1) since 1931, as he fanned 77 batters, picked up two saves and recorded a 1.69 ERA. He also led the Quakers in batting, hitting .344 with 31 hits, including two doubles.
The 1974 season saw the Quakers improve again, posting a 23-5-1 overall record and a second-place finish in the EIBL. Muhlstock was again a force to reckon with, going 10-1 from the pitcher's mound and striking out 64 batters en route to a 2.19 ERA. He also had one save on the way to All-Ivy League/EIBL first-team honors.
All his hard work culminated in an outstanding senior year. In 1975, he led the Quakers to their first Ivy League/EIBL Championship since 1943 with a 10-2 overall record and a league-leading 5-0 mark. He struck out 79 batters and recorded a 2.05 ERA. The Quakers earned the automatic bid to the NCAA Baseball Championship (District II) and, despite eight strong innings by Muhlstock, fell to Seton Hall, 7-5, in their first-round matchup. He was honored that season with first-team All-Ivy League and All-EIBL accolades and was named the Quakers' most outstanding pitcher.
Muhlstock still owns two of the top five records for strikeouts in a season dating back to when he fanned 79 batters in 1975 and 77 in 1973. He is third all-time for wins in a season with 10 victories in both 1974 and 1975. He was also named Academic All-American in 1975.
Upon graduating from Penn, Muhlstock went on to play four years of minor league baseball with the San Francisco Giants and the Chicago Cubs and played AAA baseball in his last season. In 1977, he was named to the All-Star team for the Texas League (AA). Muhlstock's post-college honors include being inducted into the Penn Baseball Hall of Fame, the Teaneck High School Athletics Hall of Fame, the Bergen County (NJ) Baseball Association Hall of Fame and the North Jersey Metropolitan Baseball League Hall of Fame.
While at Penn, Muhlstock was also a four-year starter on the junior varsity basketball team, captaining the team from 1973-75. In his final season with the Penn baseball program, the Quakers created the Andrew Muhlstock Most Valuable Pitcher Award, which subsequently was given to Muhlstock for his outstanding work on the mound that season.
“Andy Muhlstock was, without a doubt, the smartest pitcher we ever had. He never gave anyone anything to hit. He was a good student in the classroom and a good student on the mound. He had a lot of athleticism that he took to the mound every season. He also swung the bat very well. He was a winner. The teams that he played on were very strong and he was instrumental in helping us win the Ivy League and EIBL Championship in 1975.” — Bob Seddon, head baseball coach, 1970-2005.
The "Andrew Muhlstock Most Valuable Pitcher Award," given by the